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Females showed lower pain threshold and tolerance compared with men with the exception of one study295 in females had lower pain thresholds than males, but this difference was not significant, likely due to the sample size (12 F, 12 M). One study found that females provided higher ratings of suprathreshold pressure pain than males, with the sex difference increasing in magnitude with greater stimulus intensity.111 In summary, the recent literature continues to provide strong support for the hypothesis that females are more sensitive to pressure pain. Absolutely, NSFW AI girlfriends are designed to provide a much broader spectrum of interaction and engagement than solely adult entertainment.

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This suggests sex differences in central processing of nociceptive information. Table 7 also presents information about 3 studies that examined sex differences in spatial summation. Unlike temporal summation, no differences have been observed between males and females with spatial summation of heat pain88,238 or cold pain.268 Lack of sex differences might be related to the fact that spatial summation was either measured or reflected only for pain threshold in these studies, and sex differences in suprathreshold measures are often more robust than for threshold. Moreover, sample sizes were relatively small in all of these studies, which may have reduced the ability of these studies to detect sex differences. Nonetheless, the currently available data suggest no sex differences in spatial summation of pain, though additional studies with larger sample sizes would increase confidence in this conclusion. Finally, sex differences in temporal summation have also been demonstrated in clinical samples.

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• Taken together, these findings from studies of musculoskeletal pain indicate that regardless of site or time frame, females consistently are more likely to report musculoskeletal pain than males, though these differences may be less consistent for low back pain.
• First, sex differences could result from differences in the distribution, expression or sensitivity of opioid receptors in regions of the central nervous system involved in nociceptive processing.
• This section was not included in Table 10 since only a limited number of studies have addressed this issue.
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• Attention, memory, and spatial ability are key cognitive functions affected by testosterone in humans.
• Another gene, SOX3, has recently been identified as upregulating the expression of SOX9 via a similar mechanism to SRY and as being responsible for XX male sex reversal in humans through gain-of-function mutations mediated by genomic rearrangements around SOX3, possibly leading to its altered regulation10).

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Furthermore, duplications of the SOX3 locus were detected in three cases of 46,XX testicular DSD10). SOX3 analysis can be considered the next step for the diagnosis of 46,XX SRY-negative testicular DSD with normal copies of SOX9. A family study recently reported that 46,XY persons with a 178 kb duplication in a region about 500 kb upstream of SOX9 were completely normal fertile males, whereas 46,XX SRY-negative persons in the same family with duplications were clinically infertile males6). In this report, two of the three paternal cousins of their probands are known as infertile and the two probands share the same paternal haplotype for the SOX9 region, confirming the possibility that the father was indeed the carrier of the same triplication. Therefore, we should investigate family members of 46,XX male patients caused by SOX9 duplication. The 46,XX testicular disorder of sex development (DSD), also known as 46,XX male syndrome, is a rare condition with an estimated prevalence of one in 20,000 males1).

• In addition to the above findings addressing sex differences in responses to μ-opioid agonists, others have investigated analgesic responses to mixed-action opioid agonist-antagonists among women relative to men.
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• Two PET studies reported that males and females process thermal pain differently, though both the methodology and the pattern of results differed substantially between studies.

The prevalence increased with age for both sexes with greater increases for girls. The epidemiology of chronic pain in children has been reviewed by McGrath,272 but differences between boys and girls were only briefly discussed. We will review several large studies that compared the prevalence of headaches, musculoskeletal pain, and abdominal pain in children and adolescents. Another issue concerns geographic or cultural characteristics of the reference population.

More research is needed to further characterize the contribution of gender roles to the relationship between sex, gender, and pain. The results from 22 studies that examined sex differences in experimental heat pain are presented in the upper portion of Table 6. All of the studies used some form of contact heat with the exception of one study that used hot water immersion.360 Also, the forearm was the most common site for stimulus application. The vast majority of studies reported that females were more sensitive to heat pain than males. For the studies examining behavioral measures of heat pain sensitivity, 81% (12/17), and 94% (15/16) of the studies reported lower thresholds and tolerances, respectively, in females. Females were also found to rate heat pain as more intense and unpleasant in the majority of studies that included a suprathreshold protocol (7/9, 78%), and one study found that females required lower temperatures to evoke moderate pain.411 Overall, the hypothesis that heat pain sensitivity differs as a function of sex has been supported.